人奶是如何被婴儿消化和吸收的?人奶是如何被婴儿消化和吸收的?ITraq告诉你~ - bangfeishengwu - 蛋白质组学交流群——最新的文章、行业动态 Itraq告诉你~这个问题恐怕还没有人仔细的研究过。这个问题在中国也许感兴趣的人更多。让我们来看看最近发表的一篇J Proteome Res。 用模拟的胃模型消化人奶,之后用比较蛋白质学iTRAQ的方法研究奶中蛋白的变化。总的来讲,脂蛋白类是被消化的比较慢的蛋白。Mucins, ribonuclease 4,和 macrophage mannose receptor 1也比较抗消化。免疫球蛋白正如所料是难于整体乳蛋白的难消化蛋白,IgA和IgM比IgG消化的更慢。这让我想到初乳中的免疫球蛋白是可以进入婴儿体内发挥免疫作用的。

贴个abstract和大家分享一下~人奶是如何被婴儿消化和吸收的?ITraq告诉你~ - bangfeishengwu - 蛋白质组学交流群——最新的文章、行业动态

 

 J Proteome Res. 2014 Feb 7;13(2):1055-64. doi: 10.1021/pr401051u. Epub 2013 Dec 19.

Differential digestion of human milk proteins in a simulated stomach model.

Zhang Q1Cundiff JKMaria SDMcMahon RJWickham MSFaulks RMvan Tol EA.

Abstract

A key element in understanding how human milk proteins support the health and development of the neonate is to understand how individual proteinsare affected during digestion. In the present study, a dynamic gastric model was used to simulate infant gastric digestion of human milk, and a subsequent proteomic approach was applied to study the behavior of individual proteins. A total of 413 human milk proteins were quantified in this study. This approach demonstrated a high degree of variability in the susceptibility of human milk proteins to gastric digestion. Specifically this study reports that lipoproteins are among the class of slowly digested proteins during gastric processes. The levels of integral lysozyme C and partial lactadherin in milk whey increase over digestion. Mucins, ribonuclease 4, and macrophage mannose receptor 1 are also resistant to gastric digestion. The retention or enhancement in whey protein abundance can be ascribed to the digestive release of milk-fat-globule-membrane or immune-cell enclosed proteins that are not initially accessible in milk. Immunoglobulins are more resistant to digestion compared to total milk proteins, and within the immunoglobulin class IgA and IgM are more resistant to digestion compared to IgG. The gastric digestion of milk proteins becomes more apparent from this study.

   

        至今我们已经收集到了各种样品做iTRAQ的文章,包括血液,细胞,组织,尿液,泪液,现在加上一个乳液,快可以呼唤神龙了…….人奶是如何被婴儿消化和吸收的?ITraq告诉你~ - bangfeishengwu - 蛋白质组学交流群——最新的文章、行业动态

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